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What’s Lorcaserin?

Lorcaserin (Belviq) is an anti-obesity agent. If you are up for shaking off the extra body weight without fussing about tedious workouts, here’s what you should note before buying the serotonergic drug.
Lorcaserin hydrochloride was developed by Arena Pharmaceuticals. Over the years, it has been in use as a long term treatment for obesity. The supplement suppresses appetite by increasing satiation. Besides, lorcaserin effectiveness does not require you to follow some strict diet or exercise routines.
Since its inception, the drug has undergone numerous preclinical trials and human studies to ascertain its efficacy and tolerability in the treatment of obesity. In 2012, the FDA approved lorcaserin (Belviq) for therapeutic uses but under stringent measures. For instance, the prescription-only became available for obese and overweight adults who had weight-related comorbidities such as hypertension, diabetes, and dyslipidemia.
There are two popular lorcaserin brand names, that is, Belviq and Belviq XR. Both of them are almost similar, having lorcaserin hydrochloride as the active ingredient.
Belviq capsules are slightly smaller, and the dose range is split into two per day. Contrariwise Belviq XR capsules are relatively bigger. This lorcaserin brand name has orange extended-release tablets to be taken once a day.

Lorcaserin and Lorcaserin Intermediates

Racemic Chlorocaserin Hydrochloride

This compound is commonly referred to as lorcaserin hydrochloride. However, its scientific name is 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine Hydrochloride (CAS: 1431697-94-7).
Racemic Chlorocaserin Hydrochloride powder derives from mixing dextrorotatory chlorocaserin hydrochloride and lev-rotatory chlorocaserin hydrochloride. The lorcaserin intermediate is used in the study and preparation of a viable weight-loss drug.

Dextrorotatory Chlorocaserin Hydrochloride

The substance is chemically known as (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride (CAS no: 846589-98-8). However, in layman’s terms, it is (R) lorcaserin hydrochloride.
This lorcaserin intermediate is an analytical raw material for studying the pharmacological properties of weight loss medications. In preclinical studies with mice, the compound exhibits anorectic effects. Besides, it also reduces the intake of analgesics and narcotics such as caffeine, amphetamine, and related drugs.

Right-Handed Green Casserole

Scientifically, this is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine with CAS no. 616202-92-7.
The right-handed green casserole is available for analytical and study reasons. The substance is selectively agonistic to 5-HT2C receptors, hence, useful in the research of appetite-suppressant drugs.

Dextrorotatory Chlorocaserin Hydrochloride Hemihydrate

This compound is otherwise known as lorcaserin hydrochloride hemihydrate. Its scientific identity is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine hydrochloride hemihydrate (CAS: 856681-05-5).
Dextrorotatory Chlorocaserin Hydrochloride is a raw material for lorcaserin synthesis.

Racemic Chlorocaserin Free Base

Its chemical name is 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzazepine (CAS no: 616201-80-0).
Racemic Chlorocaserin Free Base is a pharmaceutical-grade product for use in research and scientific analysis.

Green Card Serin Intermediate

Its scientific name is 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride (CAS no: 953789-37-2). Green Card Serin is also an intermediate in the preparation of a lorcaserin supplement.
You should note that all these lorcaserin intermediates are only for research purposes. The compounds are not fit for human or animal consumption.

How does Lorcaserin Work?

Lorcaserin (Belviq) targets the Central Nervous System by interacting with specific hypothalamic receptors. It acts by activating serotonin 2C (5-HT2C) on the pro-opiomelanocortin neurons. This part of the brain has a hand in appetite and feeding habits. Although there are other receptor subtypes such as 5-HT2A and 5-HT2B, this drug has the highest affinity for 5-HT2C.
Lorcaserin weight loss supplement activates the 5-HT2C receptors, hence, prompting the expression of alpha-MSH hormones. Alpha-MSH acts on melanocortin-4-receptors, which send signals to the brain that you’re full.
The agonistic property of lorcaserin with the 5-HT2C receptor augments satiety, hence, reducing food intake and accelerating weight loss. According to some scientific hypotheses, this serotonergic drug modulates the levels of leptin, a hormone that plays a role in weight loss. The plus of using this supplement as an anti-obesity agent is that it does not spark off valvular heart disease. The reason is that it is less agonistic to the 5-HT2B receptors.

Lorcaserin Benefits and Side Effects


Taking lorcaserin hydrochloride increases the feeling of satiety. It helps with eating disorders, such as is common to emotional and binge eaters. According to the successful lorcaserin clinical trials, one can lose at least 5% of their body weight in 12 weeks.
Although rare, losing less than 5% of your weight while on lorcaserin means that you might never achieve any meaningful result even with long-term treatment. At this point, researchers recommend that you stop administering the weight loss supplement.
Using this serotonergic agent will undoubtedly trigger the fat-burning process. However, you should incorporate some physical activities while adhering to a low-calorie diet. Besides, lorcaserin effectiveness in weight management hinges on continuous administration. Discontinuing the dosage may negatively influence the results.
Besides weight management, lorcaserin also works by driving down the overactivation of dopamine in response to certain narcotics like caffeine, morphine, codeine, or amphetamines. The agonistic effects of the supplement on serotonin receptors make it suitable for managing psychotic disorders.
According to scientists, lorcaserin may also alleviate the symptoms of schizophrenia since it reduces the release of dopamine.

Side Effects
  • Headaches
  • Dizziness
  • Fatigue
  • Nausea
  • Anxiety
  • Back or muscle pain
  • Constipation
  • Frequent and difficult urination
  • Sleeplessness
  • Dry mouth
  • Vision changes such as blurriness
  • Cough
  • Dry eyes

More than half of the negative symptoms of lorcaserin HCl are due to overdose. You can bypass the lorcaserin side effects by sticking to the drug precautions. For example, you should not exceed the daily dosage range. In the case of an overdose, ensure to seek medical advice. Some of the reactions to check out include hallucinations, mood changes, stomach pain, irregular heartbeats, and hysteria.


Before administering lorcaserin HCl supplement, you need to consider the following contraindications and drug precautions;

  • Some users may be allergic to lorcaserin ingredients
  • Pregnant women and breastfeeding moms ought not to administer lorcaserin as it may affect the baby
  • The supplement may interact with some prescription and nonprescription drugs and interfere with their pharmacological properties
  • Lorcaserin weight loss medication is contraindicated to patients who are susceptible to cancer or those who already have the ailment

Who Can Use Lorcaserin?

Lorcaserin is therapeutically useful in the treatment of obesity. According to the FDA regulation, this serotonergic drug is only fit for overweight people with a BMI of over 27kg/m2 and obese adults with a BMI greater than 30kg/m2. However, the prescription is only valid for patients who have weight-related conditions such as dyslipidemia, high blood pressure, cardiovascular diseases, and hypertension.
Only adult patients can make a lorcaserin buy for chronic weight management. A flick through the clinical trials with the drug confirms than the human subjects were above 18 years. What’s more, its safety and efficacy in patients under 18 years has not been confirmed.
Although any obese or overweight adult can use a lorcaserin weight loss supplement, there are some contraindications to a few groups. For instance, pregnant women are out of the question. Besides, it is not clear whether the drug passes through breast milk, hence, lactating mothers are excluded from taking it.

What’s the Difference Between Lorcaserin, Cetilistat, and Orlistat?


Lorcaserin HCl is an appetite-suppressant while orlistat and cetilistat hold back hydrolysis of triglycerides into absorbable fatty acids. The supplement targets the hypothalamic region of the brain that regulates appetite and fullness. Taking lorcaserin will initiate satiety and signal the body that you are full regardless of the little amount you’ve consumed. Therefore, weight loss kicks in due to reduced food intake and food aversion.
With lorcaserin, an obese patient can lose more than 5% of their initial body weight and a waist size reduction of about 3cm. The medication shows significant changes than when using orlistat.
In 2012, lorcaserin hydrochloride won FDA approval and became a prescription drug for obesity and weight-related comorbidities. However, the Federal Agency withdrew it from the market due to the increase in cancer progression among its users.


Just like lorcaserin (Belviq), cetilistat is an anti-obesity drug. Taking the drug blocks the pancreatic lipases, which are responsible for breaking down triglycerides. As a result, the triglycerides will not hydrolyze into free fatty acids for efficient absorption into the body. Therefore, fats will be excreted undigested.
Cetilistat may lead to a decrease in up to 10% of body weight and a significant reduction in waist circumference.
Unlike lorcaserin side effects, the negative symptoms of cetilistat are mainly related to digestion. For instance, one will experience oily and loose stools, flatulence, frequent bowel movements, or fecal incontinence.
Cetilistat has not yet won the approval of the FDA because it is currently in the early phases of human studies. So far, the supplement has promising results. A comparison between the clinical stats of cetilistat and orlistat proved that the former significantly accelerates weight loss and it has better tolerability.
The plus of cetilistat is that it neither acts on other gastrointestinal enzymes nor the nervous system. This fact explains why it has fewer adverse reactions.


Both Lorcaserin and orlistat aid in weight loss. However, their mechanism of action differs.
Just like cetilistat, Orlistat temporarily inhibits the gastric and pancreatic lipases. This inhibition interferes with the hydrolysis of triglycerides from one’s diet, hence, all the absorbed fats are excreted unchanged.
According to the available clinical trials, human subjects could lose weight faster while using orlistat than those on a placebo. At the end of six months, there will be notable changes in the circumference of the waist. Besides, taking the drug reduces blood pressure and the incidence of type II diabetes.
Orlistat is an ideal lorcaserin alternative that is available as a prescription drug for treating obesity but you can also buy over-the-counter. Unlike lorcaserin, this medication is still on the whitelist of the FDA. Most states would sell the supplement without the need for a valid prescription. Take, for example, in the US, European Union, and Australia, buying orlistat is as easy as paying for a pair of sneakers. Orlistat has no effects on other GIT enzymes nor the nervous system.

In a nutshell

Cetilistat and orlistat are lorcaserin alternatives for treating overweight and obesity. However, their efficiency will only increase with physical activities and a low-calorie diet. Lorcaserin and orlistat reduce weight and waist size but discontinuing their dosages will make the user regain up to 35% of what they had lost.
So far, it is only the Cetilistat supplement that has not made it to the US FDA whitelist as it is still in the clinical trials. As for orlistat, acquiring it is more like buying your typical paracetamol. Contrary, making a lorcaserin buy is almost impossible since the US Federal Agency annulled its approval in early 2020.
All three drugs work efficiently but cetilistat has notable results. Besides, it has fewer side effects and it’s well-tolerated in the body.

Where to Buy Lorcaserin and its Intermediates?

You can make a lorcaserin buy at online stores. The powder is available in bulk for researchers and analysts. When your goal is to lose extra pounds due to obesity, you can check out lorcaserin for sale online. However, you might require a prescription as a result of the stringent guidelines by the FDA.
If you are looking for lorcaserin or its intermediates, you should check in with CMOAPI for a valid supply of pure products. Our compounds have undergone quality assurance.

Lorcaserin FAQ

How do I take belviq for best results?

Swallow the extended-release tablet whole and do not crush, chew, or break it. You may take Belviq with or without food. You should lose at least 5% of your starting weight during the first 12 weeks of taking Belviq and eating a low calorie diet.

How much weight can you lose with belviq?

Lorcaserin, used in combination with diet and exercise, results in modest weight loss of about 12.9 lb (5.8 kg) compared with 5.6 lb (2.5 kg) with placebo.

How long should you take belviq?

You may take Belviq with or without food. You should lose at least 5% of your starting weight during the first 12 weeks of taking Belviq and eating a low calorie diet. Call your doctor if you do not lose at least 5% of your starting weight after taking the medicine for 12 weeks.

How does belviq make you feel?

Belviq is known as a selective serotonin 2C receptor agonist, which means it activates very specific parts of your brain that make you feel full. Less hunger leads to less eating, which leads to weight loss.

What are the side effects of lorcaserin?

Side effects of Belviq include:low blood sugar (hypoglycemia),mental problems,slow heartbeat,headache,dizziness,drowsiness,feeling tired, fatigue,

Can you drink alcohol while taking belviq?

Do all weight loss drugs interaction with alcohol? Not all weight loss drugs have drug interactions with alcohol; for example, lorcaserin (Belviq, Belviq XR) and orlistat (Alli, Xenical) do not list alcohol drug interactions in their product labeling.

Can belviq cause weight gain?

Slim results. People who take the drug for a year can expect to lose just 3 to 3.7 percent of their weight, and may gain the weight back, research suggests. In one trial, patients taking Belviq did lose up to 5 percent of their body weight after 12 months, but gained back 25 percent of it by the end of the second year.

Which is better Contrave or belviq?

Belviq and Contrave belong to different drug classes. Belviq is a serotonin 2C receptor agonist and Contrave is a combination of an opioid antagonist and an antidepressant.

Does belviq really work?

People who take the drug for a year can expect to lose just 3 to 3.7 percent of their weight

Is belviq similar to Phentermine?

Belviq (lorcaserin hydrochloride) and Adipex-P (phentermine) are used for weight management in obese patients in addition to diet and exercise. Belviq is used for chronic weight management.

Is belviq discontinued?

The U.S. Food and Drug Administration (FDA) has requested that the manufacturer of Belviq, Belviq XR (lorcaserin) voluntarily withdraw the weight-loss drug from the U.S. market.


  1. Taylor, J., Dietrich, E., and Powell, J. (2013). Lorcaserin for Weight Management. Diabetes, Metabolic Syndrome, and Obesity.
  2. Hoy, S.M. (2013). Lorcaserin: A Review of Its Use in Chronic Weight Management. Drugs.
  3. Hess, R., and Cross, L.B. (2013). The Safety and Efficacy of Lorcaserin in the Management of Obesity. Postgraduate Medicine.
  4. Brashier, D.B., Sharma, A.K., Dahiya, N., and Singh, S.K. (2014). Lorcaserin: A Novel Antiobesity Drug. Journal of Pharmacology & Pharmacotherapeutics.
  5. Chan, E.W. et al. (2013). Efficacy and Safety of Lorcaserin in Obese Adults: A Meta-Analysis of 1-Year Randomized Controlled Trials (RCTs) and Narrative Review on Short-Term RCTs. Obese Reviews.
  6. Nigro, S.C., Luon, D., and Baker, W.L. (2013). Lorcaserin: A Novel Serotonin 2C Agonist for The Treatment of Obesity. Current Medical Research and Opinion.