Tadalafil

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What's Tadalafil

Tadalafil is a prescription drug used in treating erectile dysfunction (ED) and the symptoms of enlarged prostate in men. It is also indicated to treat pulmonary arterial hypertension (PAH).
Tadalafil (CAS Number: 171596-29-5) is found in form of an oral tablet or tadalafil powder and mainly sold under the brand name Cialis (for erectile dysfunction or benign prostate enlargement) or Adcirca (for pulmonary arterial hypertension). Tadalafil is also available in its generic form which may not have all the strengths as the original formulation


How does tadalafil work?

Tadalafil is one of the phosphodiesterase type 5 (PDE5) inhibitors. When these groups of drugs inhibit PDE5 they in turn enhance erectile function.
During sexual arousal, an erection occurs when there is enough blood flow in the penile arteries that results in relaxed arteries and smooth muscle of the corpus cavernosum. This response is moderated by the production of nitric oxide (NO) in the endothelial cells and the nerve terminals. The release of NO boosts the synthesis of cyclic guanosine monophosphate (mainly known as cyclic GMP or cGMP) in the smooth muscle cells. The cyclic GMP helps relax the smooth muscle and increases the blood flow to the corpus cavernosum.
Tadalafil inhibits phosphodiesterase type 5 (PDE5) by increasing the amount of cGMP. It is worth noting that one must experience sexual stimulation to initiate the natural release of nitric oxide. This is because Tadalafil effects will not occur without sexual stimulation.
Tadalafil can reduce the symptoms of enlarged prostate glands including urgent/frequent urination, difficulty in peeing, and urinary incontinence. It achieves this by relaxing the muscles in the prostate and bladder.
In pulmonary hypertension, tadalafil helps relax the blood vessels in the chest. This in turn helps increase the supply of blood to the lungs and also reduces the workload of the heart.


Intermediates of Tadalafil

In the process of producing tadalafil (CAS 151596-29-5), some intermediaries are formed. Some companies will use tadalafil intermediates to produce tadalafil.

Cas 171596-29-5

Tadalafil (CAS 171596-29-5) is a potent and effective prescription medicine for treating erectile dysfunction and benign prostatic enlargement in men as well as pulmonary arteries hypertension.

Cas 171489-59-1

Cas 171489-59-1 also referred to as Chloropretadalafil is an intermediate in the production of Tadalafil used in the treatment of erectile dysfunction. CAS 171489-59-1 has a molecular formula C22H19ClN2O5 with a molecular weight of 426.85 g/mol. It is available in form of a white solid.

Cas 171752-68-4

CAS 171752-68-4 whose molecular formula is C20H18N2O4.HCl and a molecular weight of 386.83 g/mol is also a tadalafil intermediate.
There are many suppliers of tadalafil intermediates who offer tadalafil intermediates for sale at competitive prices. However, when you consider tadalafil buy it from trusted companies to ensure quality is not comprised.
CMOAPI is one of the tadalafil intermediate suppliers who guarantee good quality and competitive pricing of their products.


Who and how to use tadalafil

Tadalafil powder can treat the following in men?

Erectile dysfunction

Erectile dysfunction (ED) also referred to as impotence is a condition in men in which they are unable to get or keep an erection for sufficient time to engage in sexual activity. It often leads to interest in sex and could also result in other disorders such as premature or delayed ejaculation and sometimes inability to reach orgasm.
ED can be caused by many reasons both physical and emotional conditions such as certain diseases like diabetes, heart disease, and hypertension, age, stress, or even relationship issues.
Tadalafil helps treat ED by increasing the flow of blood to the penis. This in turn helps achieve and keep an erection. However, tadalafil only helps with erection when one is already sexually stimulated.

Benign prostatic hyperplasia (BPH)

Also referred to as prostate gland enlargement, BPH is a common condition often found in men at their old age. However, several other factors could lead to enlarged prostate including diabetes and heart disorders, lifestyle, and especially obesity as well as a family history of BPH. When the prostate enlarges it could lead to urinary conditions.
The symptoms associated with the enlarged prostate gland are, urgent and frequent urge to urinate, having difficulty starting to urinate, a weak urine stream, or inability to empty the bladder fully. Other signs of BPH may include urinary tract infection (UTI), unable to urinate, or blood in the urine.
Tadalafil powder or tablet helps relax the muscle in the prostate and bladder. This helps relieve the symptoms of BPH.

Pulmonary arteries hypertension (PAH)

PAH is a condition in which there is high blood pressure in arteries that supply blood to the lungs. It is distinct from the common high blood pressure. It occurs when the arteries from the heart to the lungs become narrow or are blocked.
The most notable symptoms include chest pain, fatigue, or even swelling in your legs and ankles.
Tadalafil can help relieve the symptoms of PAH by relaxing the blood vessels in the lungs that consecutively increase blood flow.

How to use tadalafil?

The tadalafil dosage is dependent on your age, intended use, and any other underlying medical issues.
Tadalafil use is not recommended for children under the age of 18 years while also the aged beyond 65 years should be very cautious since their bodies take longer to absorb these drugs.
There are clear guidelines on how to use tadalafil powder but the most common form is the tadalafil tablet under different brand names.
It is advisable to take tadalafil once daily and to take it at about the same time every day to get tadalafil benefits.
The tadalafil dosage for various uses are defined;
For erectile dysfunction, a dose of 2.5-5 mg is taken daily or 10 mg when taken once as per need basis.
For benign prostatic hyperplasia, a dose of 5 mg taken daily is recommended. Tadalafil should be taken once daily.
When dealing with both conditions (erectile dysfunction and enlarged prostate) a dosage of 5 mg per day is appropriate.
With pulmonary arterial hypertension, a tadalafil dosage of 40 mg taken daily is suggested.
Just like other drugs, what works for one may not do the same to another. Tadalafil alternatives do exist. However, the best thing to do is to talk to your doctor about the available tadalafil alternatives and see which suits you best. You may be advised to take tadalafil alternatives if you are allergic to tadalafil or due to other reasons.
It is your responsibility to note what works well for you while you rule out tadalafil is the choice or the tadalafil side effects offset the tadalafil benefits.


Whats difference between Tadalafil and other medications for erectile dysfunction

Cialis (Tadalafil)

Cialis is a prescription medication in the class of drugs called Phosphodiesterase-5 Enzyme Inhibitors. It is used to treat the symptoms of erectile dysfunction. It can be used alone or stacked together with other drugs.

Dapoxetine Hydrochloride

Dapoxetine hydrochloride is classified as a fast-acting selective serotonin reuptake inhibitors (SSRIs).
Dapoxetine hydrochloride is a registered drug used to treat premature ejaculation. Premature ejaculation is a very common condition in men that involves the inability to delay ejaculation. This is one symptom of erectile dysfunction in men.
Although both tadalafil and dapoxetine hydrochloride are used to treat the symptoms of erectile dysfunction, one tadalafil is a phosphodiesterase inhibitor while the other, dapoxetine, is a selective serotonin reuptake inhibitor.

Vardenafil Hydrochloride

Vardenafil is a medication in a group of drugs called phosphodiesterase (PDE) inhibitors. It is used to treat male erectile dysfunction. When the man is sexually aroused, vardenafil increases the flow of blood to the penis that hence ensures you get an erection.
Vardenafil sold under the brand name Levitra is highly selective than sildenafil and tadalafil (Cialis) to PDE5. This simply means that a lower dose of vardenafil is required with few possible side effects.
Another notable difference is in the half-life where vardenafil (Levitra) has a half-life of 4-6 hours while tadalafil (Cialis) has a half-life of 17.5 hours. This hence means that Tadalafil (Cialis) acts for longer than vardenafil.

Avanafil

Avanafil is a medication in the group of phosphodiesterase inhibitors. It is also used to treat erectile dysfunction by improving the blood flow in the penile region.
Although both avanafil and tadalafil are phosphodiesterase inhibitors, avanafil is the newest and has a short half-life of about 5 hours than tadalafil which has a half-life of 17.5 hours.
In conclusion, tadalafil is more good due to its longer half-life. One can take the medication wit a few possible side effects.


Tadalafil Side effect and benefits

Tadalafil benefits

Many who consider using tadalafil powder buy it due to its main tadalafil benefits;

Treating erectile dysfunction

Penile erection is an integral process for sexual activity. Erectile dysfunction occurs when a man is unable to get and maintain an erection. This causes many issues such as distress, low esteem, and even relationship problems.
An erection is achieved when there is enough blood flow in the penis. Tadalafil helps relieve the symptoms of erectile dysfunction by increasing the flow of blood to the penis.

Treating the symptoms of benign prostatic hyperplasia

Benign prostatic hyperplasia is also referred to as an enlarged prostate gland. This a condition that occurs naturally with age. When the prostate gland becomes enlarged, it squeezes the urethra. Some of the symptoms associated with an enlarged prostate are; urgent and frequent urination, difficult to start urinating, painful urination among others.
Tadalafil benefits men suffering from benign prostatic hyperplasia by relieving these symptoms. Tadalafil powder helps relax the prostate gland as well as the bladder thus reduces the symptoms associated with a compressed bladder and urethra.

Can treat both erectile dysfunction and benign prostatic hyperplasia

Tadalafil can also help men suffering from both erectile dysfunction and enlarged prostate gland simultaneously.
When you use tadalafil in the right dosage and as recommended you reap the said benefits. Since I boost the flow of blood in the penile region and also in other areas, it is a healthy way to deal with these conditions.

Can also be used in treating symptoms pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) basically means that there is high blood pressure in the arteries that take blood from the heart to the lungs. It is however different from the regular blood pressure.
PAH occurs when the arteries supplying blood to the lungs become narrow or are blocked leading the heart to be forced to pump blood at a high rate. This fast and forced heart rate results in extreme pressure in the arteries.
Tadalafil powder does wonder by relaxing the blood vessels. This relaxation allows for a smooth flow of blood hence increases the rate of flow. This helps the heart to pump blood smoothing thus relieve the pressure that would otherwise accumulate

Improves your ability to exercise

During exercise blood flow is important to allow one to get enough oxygen as well as generate sufficient energy required.
Tadalafil can boost your exercise performance by both relaxing your blood vessels and increasing the flow of blood.

Tadalafil side effects

The most common tadalafil side effects include;

  • Headache,
  • Nausea,
  • flushing (warmth, redness, or tingly feeling),
  • stomach upset,
  • stuffy or running nose, and
  • muscle pain, back pain, and pain in your arms or legs.

Tadalafil could also lead to more serious side effects. You are advised to seek medical assistance if you experience any of the following tadalafil side effects;

  • some heart attack symptoms that include chest pain, pain spreading to the jaw or shoulder, nausea, and sweating.
  • vision changes including blurred vision or sudden vision loss.
  • flushing (warmth, redness, or tingly feeling),
  • Hearing impairment in
  • ringing in your ears and hearing loss
  • An erection that is painful or lasts longer than 4 hours as this could damage your penis.
  • Vomiting
  • Irregular heartbeat
  • Fainting, dizziness and,
  • Unusual fatigue.

Drug Interactions of Tadalafil

Several tadalafil interactions with other drugs have been reported. Drug interactions usually alter the function of the medications and could hinder the drugs from working properly.
It is therefore highly advised to discuss your medications before you use tadalafil. Some tadalafil interactions may be mild and other adverse.
Below are the tadalafil interactions;

Nitrates

They are also referred to as Anguina drugs. When nitrates are taken together with tadalafil, it can result in the blood pressure dropping to extremely low levels. The low level of blood pressure is associated with symptoms such as dizziness or even fainting.
Some of these anguina drugs include; butyl nitrite, amyl nitrite, isosorbide dinitrate, nitroglycerin, and isosorbide mononitrate.

Alpha-blockers

These are drugs used in correcting high blood pressure. They are also used in prostate treatment. Both tadalafil and alpha-blockers are vasodilators that possess blood pressure lowering effects. When used together, it can result in a drastic/significant drop in blood pressure. This causes one to become dizzy and could also faint.
Some of the alpha-blockers drugs include; terazosin, tamsulosin, alfuzosin, and prazosin.

Some HIV drugs

These drugs are protease inhibitors and hence can increase the level of tadalafil in the blood. This increase results in low blood pressure. It can also cause priapism in men which means they get an extended erection that’s often painful.
Some of these drugs are ritonavir and lopinavir.

Antibiotics

Tadalafil interactions with antibiotics have been reported. When taken together with tadalafil, antibiotics can increase the level of tadalafil in the blood which leads to lowered blood pressure. His can result in dizziness, fainting, and even some vision issues. It can also cause priapism in men.
Some of these drugs are erythromycin, telithromycin, and clarithromycin.
However, certain antibiotics can lower the levels of tadalafil in the blood. These tadalafil interactions make not work properly. These drugs include; rifampin.

Antifungal drugs

Some oral antifungal drugs including ketoconazole and itraconazole interact with tadalafil.
These drugs can raise the level of tadalafil which leads to dizziness and fainting could also happen.

Other pulmonary hypertension drugs

Tadalafil and other pulmonary hypertension drugs are known to have blood-pressure-lowering effects. When used together it could lead to dangerously low levels of blood pressure. This results in low blood pressure-associated symptoms such as dizziness and fainting.
The drugs include riociguat.

Antacids

These drugs are used to relieve stomach acid. When used in combination with tadalafil, they may hinder the absorption of tadalafil in the body. They include magnesium hydroxide or aluminum hydroxide.

Epilepsy medications

These are also called anti-seizure drugs. When you take anti-seizure drugs together with tadalafil, they may lower the absorption of tadalafil. This means that tadalafil will not be able to work well. These epilepsy drugs include phenytoin, phenobarbital, and carbamazepine.


Where to buy Tadalafil?

You can make a Tadalafil buy at online stores. The powder is available in bulk for researchers and analysts. Be sure to check for tadalafil powder approved suppliers.When you consider taking tadalafil buy it from the trustworthy vendors.
Consult your medical practitioner before taking tadalafil due to the possible tadalafil side effects as well as tadalafil interactions with other drugs.
If you are looking for Tadalafil or its intermediates, you should check in with CMOAPI for a valid supply of pure products. Our compounds have undergone quality assurance.


References
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  2. "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra". U.S. Food and Drug Administration (FDA). 2007-10-18. Archived from the original on 2016-10-22. Retrieved 2009-09-28.
  3. "Cialis tadalafil PI". Therapeutic Goods Administration. Retrieved 2020-08-19.
  4. Karabakan M, Keskin E, Akdemir S, Bozkurt A (2017). Effect of tadalafil 5mg daily treatment on the ejaculatory times, lower urinary tract symptoms and erectile function in patients with erectile dysfunction. International Braz j Urol: Official Journal of the Brazilian Society of Urology. 2017 Mar-Apr;43(2):317-324. DOI: 10.1590/s1677-5538.ibju.2016.0376.
  5. "Pill Splitting" (PDF). Consumer Reports Health. 2010-01-25. Archived from the original (PDF) on 2008-10-08.
  6. Wang Y, Bao Y, Liu J, Duan L, Cui Y (January 2018). "Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta-analysis". Low Urin Tract Symptoms. 10 (1): 84–92. doi:10.1111/luts.12144. PMID 29341503.