Avanafil is used to treat erectile dysfunction (ED: impotence; inability to get or keep an erection in men). Avanafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Avanafil does not cure erectile dysfunction or increase sexual desire. Avanafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV,hepatitis B, gonorrhea, syphilis).To decrease your risk of infection, always use an effective barrier method (latex or polyurethane condom/dental dams) during all sexual activity. Consult your doctor or pharmacist for more details.
Avanafil powder Base Information
|Solubility||nsoluble in water or alcohol, soluble in Acetic acid, ethyl ester.|
Did you know that over 30 million men in the United States have erectile dysfunction (ED)? That explains why there are many ED medications sold in the US. One such drug is avanafil. Stendra is the avanafil brand name that you might be familiar with.
Avanafil (Stendra) is a PDE-5 (phosphodiesterase-type 5) inhibitor that blocks PDE-5.
When you take this drug, it will relax certain blood vessels and muscles in your body to help you get an erection by increasing blood flow to your penis. For this reason, it is used to treat erectile dysfunction (ED). Just like Levitra® (vardenafil), Cialis® (tadalafil), and Viagra® (sildenafil), avanafil will make it easier for you to erect and maintain the erection for some time.
Avanafil (Stendra®) is relatively new, having been developed in the 2000s by Mitsubishi Tanabe Pharma in Japan. The United States Food and Drug Administration (FDA) approved the drug in April 2012 for the treatment of ED, while the European Medicines Agency (EMA) approved it in June 2013.
From many avanafil reviews, you’ll notice that it has fewer side effects compared to Levitra, Cialis, Viagra, and other ED medications.
Let’s dig deeper and find out more about this drug.
How Avanafil Treats Erectile Dysfunction
Avanafil is used to treat ED or impotence, which is defined as the inability to get and maintain an erection. Avanafil falls in the category of drugs that inhibit phosphodiesterase.
Note that for you to get an erection, your penile blood vessels get filled with blood. This happens when these blood vessel’s sizes increase, thus transmitting more blood to your penis. At the same time, the size of the blood vessels taking away blood from your penis will decrease hence ensuring blood stays more in your penile muscles, thus sustaining the erection longer.
When you are sexually stimulated, you should get an erection. This erection will make your penis release nitric oxide, a compound that will cause guanylate cyclase (an enzyme) to produce cGMP (cyclic guanosine monophosphate), an important intracellular messenger that regulates many physiological processes.
Actually, it is this cyclic nucleotide that’s responsible for the relaxation and contraction of blood vessels that carry blood from and to the penis to cause an erection. When another enzyme destroys cGMP, the blood vessels will regain their original sizes causing blood to leave the penis, and that will mark the end of an erection.
When you take avanafil, it will stop PDE-5 from destructing cGMP, meaning the cGMP will stay longer and sustain your erection. The longer the cGMP stays, the longer the blood will stay in your penis and the longer your erection will take.
Is Avanafil (Stendra) Effective for Treating Erectile Dysfunction?
Although avanafil (Stendra) is a new ED medication, many studies prove its efficacy in ED treatment. In some five studies conducted in 2014 to find out whether this drug is effective, over 2,200 men participated, and all of them had erectile dysfunction.
At the end of the studies, avanafil was found to be very effective in improving the IIEF-EF, the international index used to assess problems related to erections.
All the men who took this drug showed remarkable improvements in their IIEF-EF at doses ranging from 50 to 200mg. The research results also showed that avanafil was more effective at higher doses of 200mg. This differentiates avanafil from other ED drugs that cause adverse side effects at higher doses.
In another study conducted in 2012, avanafil was found to be well tolerated and very effective in ED treatment. Two of the men who took part in the study showed remarkable improvement at doses of between 100 to 200mg.
In clinical trials involving avanafil, researchers reported that it demonstrates a statistically significant boost in all ED-related efficacy variables. These trials involved over 600 men in the age bracket of 23 – 88.
In a nutshell, avanafil is effective in the treatment for ED. Several studies have proved that it can produce measurable and significant improvements in erection for all men with ED, regardless of their ages.
Which is Better Avanafil or Tadalafil?
Avanafil is the newest ED drug on the market, but it does better than many old ED medications. Both Avanafil or Tadalafil are used to treat erectile dysfunction, but they have some differences in their mode of action.
While tadalafil (Cialis) is an effective remedy for both enlarged prostate and erectile dysfunction symptoms, Stendra is usually the first choice for those who have erectile dysfunction.
Avanafil vs Tadalafil: Which one works faster?
Tadalafil and other first-generation erectile dysfunction drugs take between 30 minutes to one hour for their effects to be felt. And in some cases, after you’ve eaten something heavy, the drugs can take more than one hour to start functioning. This is not the case with avanafil.
If you take between 100 – 200mg of the product, you’ll feel the avanafil effect within 15 minutes. Meaning you can take it just a few minutes before you start having sex. Even if you take a lower dose of avanafil, say 50mg, you’ll still get an erection within 30 minutes.
Avanafil vs Tadalafil: Which one Has Fewer Side Effects?
Although avanafil has some side effects, these side effects aren’t as many as those of tadalafil. The avanafil side effects are also not as adverse as those of tadalafil. For example, avanafil is not likely to cause low blood pressure and impaired vision; the two side effects associated with tadalafil and other ED medications.
Another advantage of avanafil is that it can be taken at higher doses without causing any side effects. In fact, higher doses of up to 200mg can be taken without worrying about any side effects.
Avanafil acts differently from tadalafil because it targets the phosphodiesterase-type 5 enzyme, without attacking other phosphodiesterase enzymes such as PDE11, PDE6, PDE3, and PDE1.
Avanafil Isn’t Affected by Food.
Tadalafil and other first-generation erectile dysfunction medications are often less effective after eating large meals of foods with high-fat content. This makes it a big challenge to use them since you have to monitor your eating time and also be sensitive about what you eat.
On the other hand, avanafil isn’t affected by the food eaten, meaning you’ll enjoy the avanafil effect no matter the time you eat and what you eat. For this reason, it is even better to eat high energy foods before using this medication so you can have enough energy for your sexual performance.
Avanafil vs Tadalafil: Which one can be Used With Alcohol?
It is advisable to limit or avoid alcohol when on a tadalafil medication. Tadalafil is known to lower blood pressure, so taking it together with alcohol can further lower the blood pressure to acute levels.
Taking this drug with alcohol is associated with symptoms such as heart palpitations, headache, flushing, fainting, lightheadedness, and dizziness. On the other hand, Stendra is very safe to use, even after taking alcohol. You can enjoy up to three alcohol servings before taking Stendra, and there won’t be any side effects and any other risks on your health.
However, this doesn’t mean you can go on a binge then use Stendra. You have to use alcohol in moderation since alcohol itself also causes some health problems. Alcohol is a sedative, and when you use too much of it, it will decrease your sexual desire and make it difficult for you to get an erection. It means alcohol negates what ED medications aim to achieve.
As can be seen, avanafil has several benefits over tadalafil. That’s why many medics like to prescribe it to their patients.
What Other Drugs Will Affect Avanafil?
While some drugs can not be used in combination, some can be combined to enhance their effectiveness. Drugs that can not be combined are those that interact with one another and cause an adverse effect. That’s why before you are put on any medication, let your know if you are already on another drug. This should also be the case if you want to change drugs or dosage. Don’t do anything on your own without involving your healthcare provider.
For example, you are strongly advised against using avanafil in combination with drugs such as Levitra, Staxyn (vardenafil), tadalafil (Cialis), or Viagra (sildenafil). These drugs are also used to treat ED and arterial hypertension (pulmonary). So using them together with avanafil can overload your body and cause serious side effects.
Before you start using avanafil, let your health provider know if you are taking any other medications, especially:
- The drugs used to treat erectile dysfunction.
- Any antibiotics such as telithromycin, erythromycin, clarithromycin, and others
- All antifungal drugs, among them ketoconazole, itraconazole, and others
- Any drug used for the treatment of a prostate disorder or high blood pressure, including tamsulosin, terazosin, silodosin, prazosin, doxazosin, alfuzosin, and others.
- Hepatitis C drugs like telaprevir and boceprevir and others.
- HIV/AIDS drugs such as saquinavir, ritonavir, indinavir, atazanavir, and others.
The lists above are by no means comprehensive. There are other drugs like Doxazosin and Tamsulosin that when used together with avanafil will result in acute side effects. Additionally, many other over-the-counter and prescription drugs may interact with avanafil. These include herbal products and vitamins. The bottom line is that don’t use any drug in combination with avanafil without the knowledge of your doctor.
It is not only drugs that you should be wary about, but you should also be cautious when you have some underlying medical conditions. So before you use avanafil, let your doctor know if you have any of the following medical problems.
- Abnormal penis – if you have a curved penis or your penis has some congenital disabilities, there are high chances that your health may be affected if you use avanafil.
- If you are 50 years of age or older
- If you are suffering from a crowded disc, coronary artery disease, or your eyes have a low cup-to-disc ratio, and if you are suffering from heart disease or diabetes, high-fat levels in the blood (Hyperlipidemia) or high blood pressure (hypertension).
Other conditions that you should bring to the attention of your doctor include:
- Severe eye problems
- Serious chest pain (angina)
- Irregular heartbeat (arrhythmia)
- Problems with blood vessels such as idiopathic subaortic stenosis or aortic stenosis
- Heart attack experienced within the last six months.
- Congestive heart failure
- History of smoking
- Low blood pressure (hypotension)
- Retinal disorders
- Retinitis pigmentosa
- Stroke within the last six months
- Bleeding disorders
- Stomach ulcers
- Blood-related cancer (leukaemia or multiple myeloma)
- Sickle-cell anaemia, among others
PDE5 inhibitors, Stendra included, do interact with some CYP3A4 inhibitors and alpha-blockers. For this reason, it’s important to let your doctor know if you are using these medications. Overall, avanafil is an effective and safe product for ED treatment.
Avanafil is mainly used to treat erectile dysfunction. Some avanafil benefits include the fact that it works faster than all other medications used for ED treatment. You can take it fifteen minutes before you have sex and it will still be effective.
Another advantage of avanafil is that you don’t have to take it daily to be effective, you can take it as and when you need it. Avanafil is well tolerated by the body and can be taken with or without food. Avanafil doesn’t have as many side effects as other ED medications, and you can as well take it after drinking alcohol.
The treatment of ED is just one of the avanafil uses. This product is also used for the treatment of Raynaud’s phenomenon, a disorder that results in some part of the body feeling cold and numb. Raynaud’s phenomenon occurs when there is a decrease in blood flow to the part of the body, such as the nose, knees, nipples, toes, and ears. This condition also causes changes in skin color.
How to Benefit More From Avanafil
Avanafil will help you get an erection, but that doesn’t mean you can do away with foreplay. So before you have sex, engage your partner in foreplay the same way you would have done without taking medicine. Remember that avanafil will only help you get an erection when you are aroused sexually.
Don’t drink a lot of alcohol before you use avanafil. Too much alcohol may prevent you from enjoying the avanafil effect to the fullest. Combining alcohol and avanafil may cause side effects such as dizziness which will lower your sex drive and performance.
Avoid drinking grapefruit juice within 24 hours that you plan to take avanafil and have sex. Grape juice contains certain chemicals that will increase avanafil levels in your bloodstream hence increasing the chances of experiencing some side effects.
Honor your appointments with the healthcare provider so he can monitor your progress. If you fail to get an erection even after taking avanafil and engaging in foreplay, or if you get an erection, but it doesn’t last long enough to have sex and reach an orgasm, you need to let your doctor know.
The same applies if the avanafil seems to be too powerful for you; when your erection seems not to fade after you are done with sex. Let your doctor know about this so he can reduce your dosage. Also, remember not to take more avanafil than what your doctor prescribes.
Using Avanafil (Stendra)
For avanafil to be effective, it would help if you took it as prescribed by your doctor. The doctor will tell you how much to take and at what times.
Just like other erectile dysfunction medications, avanafil is easy to use. The medicine comes in powder or tablet form. Since avanafil acts fast, you need to take it between 15 – 30 minutes before having sex. If your doctor prescribed for you a low dose of avanafil, say 50mg a day, it’s recommended that you take the drug not less than 30 minutes before you have sex. That’s the best way to ensure your body fully absorbs the medicine. It is worth noting that you can take avanafil powder when hungry it won’t have any negative effect on your body.
It is recommended that you take this medicine only once per day. Your healthcare provider will monitor how your body responds to the medicine and may adjust the dose for you to get the full avanafil benefits.
Being a prescription medicine, you’ll have to talk to your doctor to give you a prescription before avanafil buy. The doctor will ask you several questions and, if possible, carry out some tests to help determine what avanafil dosage is suitable for you depending on your general health, age, and other medication you might be using. Stick to the avanafil uses as per the information on the product label or as indicated by your doctor. Remember that avanafil doesn’t treat medical conditions other than ED and Raynaud’s phenomenon.
Avanafil is available in three different strengths: 50, 100, and 200mg. It is most likely that your doctor will start you on the 100mg strength, but may change the dosage depending on how your body responds. Each time you buy avanafil powder, check the label to ensure you have the right strength that was prescribed for you.
Evaluation of ED must include a complete medical assessment to find out whether there are underlying causes, and also determine other treatment options. For example, a combination of psychological and physical issues can cause ED.
Some physical conditions slow sexual response resulting in anxiety that may affect sexual performance. When these conditions are treated, the sexual drive can be restored. Common physical causes of ED include:
- Atherosclerosis (clogged blood vessels)
- Heart disease
- High blood pressure
- High cholesterol
- Metabolic syndrome — This is a condition in which there’s an increase in blood pressure, insulin levels, cholesterol, and body fat.
- Multiple sclerosis
- Parkinson’s disease
- Tobacco use
- Peyronie’s disease — if scar tissue develops in the penis
- Alcoholism and substance/drug abuse
- Sleep disorders
- Injuries or surgeries in the spinal cord or pelvic area
- Treatments for enlarged prostate or prostate cancer
- Low testosterone
The brain plays a big role in sexual arousal. Several things that affect sexual stimulation start from the brain. The psychological causes of ED include:
- Anxiety, depression, or other conditions affecting mental health
- Relationship problems that result from poor communication, stress, or other concerns
- An unsatisfactory sex life
- low self-esteem or embarrassment or
- The inability to impregnate your partner
Before your healthcare provider prescribes avanafil to you, he’ll look at not only the above issues, but also the following:
If you have a pre-existing cardiovascular condition, you may have a cardiac risk when you engage in sex. For this reason, erectile dysfunction treatment using avanafil is not recommended for those who have an underlying cardiovascular condition.
Patients whose left ventricles are obstructed or those with impaired autonomic blood pressure control are susceptible to Stendra and other vasodilators.
Some users of PDE5 have reported an erection that lasts for more than four hours. Some have also reported painful erections that last for more than six hours (priapism). If you experience any of these conditions, you should seek urgent medical attention. This is because your penile tissue can get damaged if you delay and you can lose your potency permanently.
Patients with penile anatomical deformations (Peyronie’s disease, angulation, or angulation) should use avanafil with a lot of caution. Likewise, those patients with conditions that can cause priapism should also be careful when using avanafil.
Loss of eyesight
If you experience loss of vision in the course of using Stendra or any other PDE5 inhibitors, you should let your doctor know as soon as possible so you can receive the appropriate medical attention.
Vision loss can be a sign of NAION, a condition that occurs in some people who use PDE5 inhibitors. From many avanafil reviews, you’ll notice that this is an infrequent condition, but you should be aware of it.
This is another rare condition associated with PDE5 inhibitors. If you are using avanafil and you experience sudden loss or decrease of hearing, alert your doctor as soon as possible. The hearing loss is often accompanied by dizziness or tinnitus, but it isn’t obvious that these symptoms must result from PDE5 inhibitors.
It’s upon the doctors to determine the real cause of these symptoms, but in case you experience them, it would help if you stopped taking avanafil until you get a proper diagnosis from a doctor.
Avanafil Side Effects
Stendra is a safe, effective medication that only has few side effects, none of which are prevalent. For example, headaches, the most common side effect of Stendra, only affect five to 10 percent of men who use the medication.
Another common side effect of avanafil is flushing. From avanafil reviews, it has been found that this condition occurs in between 3 – 4% of users. Headaches and flushing results from avanafil’s effect on blood flow and these side effects usually fade away after some hours. Other avanafil side effects include nasal congestion, cold symptoms (nasopharyngitis), and back pain. All these avanafil side effects occur in a small percentage of users.
Where to Buy Avanafil
Do you want to buy avanafil? If so , you must choose a trusted avanafil supplier who can guarantee you that the avanafil powder you are buying is of the best quality. We are such a supplier. We source our products directly from CMOAPI, a renowned avanafil manufacturer.
CMOAPI manufactures not only avanafil but also other erectile dysfunction drugs. Do not worry about avanafil cost. We want to partner with you to supply you with avanafil for many years. That’s why our avanafil cost is very pocket friendly.
- “FDA approves Stendra for erectile dysfunction” (Press release). Food and Drug Administration (FDA). April 27, 2012.
- “Spedra (avanafil)”. European Medicines Agency. Retrieved 17 April 2014.
- US 6797709, Yamada K, Matsuki K, Omori K Kikkawa K, “Aromatic nitrogen-containing 6-membered cyclic compounds”, issued 11 December 2003, assigned to Tanabe Seiyaku Co
- “VIVUS Announces Avanafil Partnership With Menarini”. Vivus Inc. Archived from the original on 2015-12-08.
- “VIVUS and Metuchen Pharmaceuticals Announce License Agreement for Commercial Rights to STENDRA”. Vivus Inc. 3 October 2016.
- 2021 Most Authoritative Sex-enhancing Drugs Guide For Treating Erectile Dysfunction (ED).
- 1-[[2-(4-Chlorophenyl)ethyl]amino]-2-chloropropane hydrochloride (953789-37-2)
- Lorcaserin hydrochloride hemihydrate (856681-05-5)
- (R)Lorcaserin hydrochloride(846589-98-8)
- Lorcaserin hydrochloride