Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine.which received regulatory approval in 1997. Cetilistat is a novel inhibitor of pancreatic lipase being developed by Alizyme ,These drugs act in the gastrointestinal tract to inhibit lipases, enzymes involved in the breakdown of dietary fats. By inhibiting the breakdown and subsequent absorption of fats from the gut, lipase inhibitors reduce fat intake and calories, thus aiding weight loss.
Since successful management of obesity is likely to require long-term compliance with prescribed medication, cetilistat may have benefits over currently marketed anti-obesity drugs with respect to better toleration. Encouragingly, the FDA has allowed Alizyme the opportunity to consider a separate IND for the use of cetilistat for diabetic patients, potentially extending its use in the huge market for diabetes treatments.
|Solubility||nsoluble in water or alcohol, soluble in Acetic acid, ethyl ester.|
|Molecular Weight||316.31 g/mol|
|Storage Temp||Room Temperature|
Cetiaster is different from other weight loss drugs that work through the brain by reducing one’s appetite,such as sibutramine and lorcaserin HCL.
Cetilistat works by blocking the breakdown and absorption of fat. By forming a covalent bond with the active serine site of gastric lipase and pancreatic lipase to inactivate the enzyme.Inactivated enzymes cannot hydrolyze the fats in food, mainly triglycerides, into absorbable free fatty acids and monoacylglycerols. Undigested triglycerides cannot be absorbed by the body, Once the triglycerides cannot be absorbed as fatty acids in the body, they undergo excretion.Consequently, there is reduced energy intake leading to weight loss.
Cetilistat is one of the best Weight loss supplements as well as obesity treatments. Other than helping you lose weight, Cetilistat helps you maintain a healthy lifestyle. That is through assisting you in maintaining a healthy BMI.Cetilistat is safe and will rarely cause severe side effects. In this case, majority of the effects are manageable and may go away with time.
Cetilistat can provides results within a short time,Cetilistat gives you that bikini body within twelve weeks. So if your wedding or vacation is around the corner, then you could give it a try.
The clinical efficacy and safety of cetilistat has been demonstrated in a series of Phase II trials. A Phase IIb clinical trial in 612 clinically obese diabetic patients showed that over a 12-week treatment period, cetilistat 80mg and 120mg promoted significant weight loss compared with placebo (3.85kg and 4.32kg versus 2.86kg respectively), thus meeting the trial’s primary endpoint.
The dose will be different for different patients. So please follow your doctor’s orders or double check the directions on the label before taking this medicine. The following information includes only the average doses of this medicine. If your dose is different, Please dont adjust the dose without informing your doctor,Never change the dose unless your doctor tells you to do so.Otherwise it might lead to severe side effects or can’t achieve the expected effect.
Before starting Cetislim,Tell your doctor about your in-use list of medications is needed,
Dosages of 80-120 mg are usually prescribed. Do not exceed unless advised.And take it 1hour after the meal or during the meal,
while using Cetilistat, a hypo caloric diet is recommended.
Cetilistat is also contraindicated with warfarin and levothyroxine as this could cause increased risk of bleeding and hypothyroidism
What happens if you miss a dose?
If a dose is missed, take it at the earliest when you remember.
If you recall that you’ve missed a dose and it’s time for your next dose, then do not take it an till an hour before your next scheduled dose.
An extra dose should not be taken to make up fora missed dose.
Most of the Cetilistat side effects are gastro and digestive tract related.
Reduced level of bet
Reduction in vitamin E and D levels
Malabsorption of vitamins
Other side effects may include;
Change in consciousness
Abdominal pains, stomach-ache, and cramps
Difficulty walking, thinking or speaking
Shaking of hands and feet
Redness of the neck, arms, face and occasionally, upper chest
Pain or discomfort in the neck, back, jaw and arms
Tingling or numbness in the legs
Increased frequency of urinating
Difficulty or painful urination
Chest pain or discomfort
Severe mental change
Hearing or seeing things that are not there
You may consider using Cetilistat (282526-98-1) in case you want to lose weight. It could also be important for you if you meet any of the following;
Your BMI is more than 27, and you are suffering from an obesity-related health problem such as high blood pressure and diabetes.
Your BMI is higher than 27.
However,Not everyone with these conditions should take this weight loss drug.
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