Sesamol is a natural phenolic compound, a main lignan, extracted from sesame (sesame) and sesame oil; and the average content of sesame in sesame is the highest, it is a white crystalline solid, Is a derivative of phenol. It is slightly soluble in water, but miscible with most oils..
|Solubility||nsoluble in water or alcohol, soluble in Acetic acid, ethyl ester.|
|Molar mass||138.12 g/mol|
|Melt Point||62 to 65 °C (144 to 149 °F; 335 to 338 K)|
|Boiling point||21 to 127 °C (250 to 261 °F; 394 to 400 K) at 5|
Sesamol, together with its conjugated metabolites, is distributed in body tissues like liver, brain, lungs as well as the kidneys.
When Sesamol is absorbed in the body, it protects DNA from damages and enhances DNA repair to rectify afterγ-radiation damage.
Because of its varied vivo bioactivities, sesamol plays an important role in the treatment of various diseases. One study established that sesamol inhibits the HepG2 cell colony formation. This supports other studies that suggest that Sesamol powder (533-31-3) ruins the viability of the cancer cells.
Normally, the majority of cancer cells need more oxidative stress as compared to the healthy cells in order to maintain the proliferation-apoptosis balance.
Some studies indicate that the interaction of sesamol and DNA is likely to take place at the latter’s groove. Still on that, another research study shows that the cell cycle that has been induced by sesamol arrest at S phase, and this happens in a concentration-dependent way. This is how sesamol causes DNA damage and obstructs the replication of DNA.
Sesamol synthesis from Sesame oil is the easiest of the three methods. However, is quite costly. So this method is not ideal for industrial production, especially due to high production costs.
Although it is fairly economical for large scale Sesamol prodution, the entire route for sesamol synthesis from piperamine applies for small scale production when hydrolysis and hydrolysis process is employed. In such a case, pigment formation as a result coupling and side reaction is unavoidable.
Semi-synthetic route originating from jasmonaldehyde is the most widely used sesame phenol synthesis process as far as industrial purposes are concerned. The process involves oxidation and hydrolysis and because of that, the resulting sesame phenol is of high quality and great color.
The process uses cost-efficient oxidant and reactive extraction technology, enabling quick separation of the product from the extraction zone. This minimizes the possibility of side reaction occurrence significantly. No wonder the final product (white-like crystal) is of high quality in terms of colour and sesamol density.
Being a natural food extract with robust Antioxidant properties, sesamol can be used to make animal meat particularly, pork and beef, has an extended shelf life. It prevents the oxidative deterioration in stored meat, making it remain in good shape without introducing elements that might have pose health risks to consumers.
In addition, the study found that double-layer packaging and combination with anti-oxidation ingredients such as sesame phenol can effectively inhibit the color change of turkey breast raw meat and cooked meat, lipid peroxidation and volatilization and dispersion loss, so as to achieve the effect of preservation.
A series of research studies have revealed the ability of sesamol in the prevention of the growth of lukemia cells in humans. The natural oxidant offers this benefit in a concentration-dependent way. Fortunately, unlike some other potential anti-tumor compounds, sesamol doesn’t cause any adverse effect on normal human cells.
Free radicals can cause various health conditions if their normal formation and elimination equilibrium is unbalanced. Besides, free radical imbalance can speed up the aging process in a human.
in addition, sesamol can inhibit the generation of hydroxyl radicals and superoxide anions, thereby affecting the body The oxidative stress state and liver function defects have a certain regulatory effect.
Metabolic syndrome refers to a pathological health issue that results from metabolic disorders like Obesity, hyperinsulinemia, diabetes and hyperlipidemia.
Sesamol can improve obesity (too much fat tissue accumulation in the body) by:
Reducing lipogenic gene expression
Boosting lipolytic gene Ppara expression
Cutting down on the expression of the genes that are responsible for cholesterol generation (Hmgcr and Acat2)
Just like sesamin, sesamol can improve the function of the mitochondria in the liver as well as the adipose tissue, thereby preventing obesity.
The environment we are living in is highly prone to lots of possibly harmful radiation, thanks to science and technological advancements. Fortunately, according to a study by Nair G G et al to establish the anti-radiation potential of sesamol, the researchers found out that the compound offers DNA and cell membrane remarkable protection from radiation damag
If you are interested in Sesamol raw powder, Please help to contact us,We are Sesamol raw materials supplier for several years, We supply products with competitive price,good customer service and quality products,
We are flexible with the customization of orders to suit your specific need and our quick lead time on orders guarantees that you’ll enjoy with our service. We are also available for service questions and information to support your business.